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mtorc2 activator sc79  (Millipore)


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    Structured Review

    Millipore mtorc2 activator sc79
    Two autophagy inducers showed a dramatic difference in neuroprotective effects in the ONC model. Treatment with p62 siRNA results in a favorable neuroprotective effect by triggering specific mTORC1 deactivation and maintaining <t>mTORC2</t> activation, which leads to the reduction in neuroinflammation through BOB protection and M2 macrophage polarization. Rapamycin can activate autophagy but provides no protection in the ONC model because the inactivation of mTORC2 results in BOB disruption, which may induce macrophage infiltration and pro-inflammatory cytokine-induced optic nerve damage
    Mtorc2 Activator Sc79, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mtorc2+activator+sc79/pmc06802655-50-12-17?v=Millipore
    Average 90 stars, based on 1 article reviews
    mtorc2 activator sc79 - by Bioz Stars, 2026-08
    90/100 stars

    Images

    1) Product Images from "mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury"

    Article Title: mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury

    Journal: Experimental & Molecular Medicine

    doi: 10.1038/s12276-019-0298-z

    Two autophagy inducers showed a dramatic difference in neuroprotective effects in the ONC model. Treatment with p62 siRNA results in a favorable neuroprotective effect by triggering specific mTORC1 deactivation and maintaining mTORC2 activation, which leads to the reduction in neuroinflammation through BOB protection and M2 macrophage polarization. Rapamycin can activate autophagy but provides no protection in the ONC model because the inactivation of mTORC2 results in BOB disruption, which may induce macrophage infiltration and pro-inflammatory cytokine-induced optic nerve damage
    Figure Legend Snippet: Two autophagy inducers showed a dramatic difference in neuroprotective effects in the ONC model. Treatment with p62 siRNA results in a favorable neuroprotective effect by triggering specific mTORC1 deactivation and maintaining mTORC2 activation, which leads to the reduction in neuroinflammation through BOB protection and M2 macrophage polarization. Rapamycin can activate autophagy but provides no protection in the ONC model because the inactivation of mTORC2 results in BOB disruption, which may induce macrophage infiltration and pro-inflammatory cytokine-induced optic nerve damage

    Techniques Used: Activation Assay



    Similar Products

    mtorc2 activator sc79  (Millipore)
    90
    Millipore mtorc2 activator sc79
    Two autophagy inducers showed a dramatic difference in neuroprotective effects in the ONC model. Treatment with p62 siRNA results in a favorable neuroprotective effect by triggering specific mTORC1 deactivation and maintaining <t>mTORC2</t> activation, which leads to the reduction in neuroinflammation through BOB protection and M2 macrophage polarization. Rapamycin can activate autophagy but provides no protection in the ONC model because the inactivation of mTORC2 results in BOB disruption, which may induce macrophage infiltration and pro-inflammatory cytokine-induced optic nerve damage
    Mtorc2 Activator Sc79, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mtorc2+activator+sc79/pmc06802655-50-12-17?v=Millipore
    Average 90 stars, based on 1 article reviews
    mtorc2 activator sc79 - by Bioz Stars, 2026-08
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Two autophagy inducers showed a dramatic difference in neuroprotective effects in the ONC model. Treatment with p62 siRNA results in a favorable neuroprotective effect by triggering specific mTORC1 deactivation and maintaining mTORC2 activation, which leads to the reduction in neuroinflammation through BOB protection and M2 macrophage polarization. Rapamycin can activate autophagy but provides no protection in the ONC model because the inactivation of mTORC2 results in BOB disruption, which may induce macrophage infiltration and pro-inflammatory cytokine-induced optic nerve damage

    Journal: Experimental & Molecular Medicine

    Article Title: mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury

    doi: 10.1038/s12276-019-0298-z

    Figure Lengend Snippet: Two autophagy inducers showed a dramatic difference in neuroprotective effects in the ONC model. Treatment with p62 siRNA results in a favorable neuroprotective effect by triggering specific mTORC1 deactivation and maintaining mTORC2 activation, which leads to the reduction in neuroinflammation through BOB protection and M2 macrophage polarization. Rapamycin can activate autophagy but provides no protection in the ONC model because the inactivation of mTORC2 results in BOB disruption, which may induce macrophage infiltration and pro-inflammatory cytokine-induced optic nerve damage

    Article Snippet: To evaluate the therapeutic effect of mTORC2 activation in the rapamycin-treated group, mTORC2 activator SC79 (10 μg, Sigma-Aldrich, MO, USA; n = 6) was injected into rapamycin-treated rats.

    Techniques: Activation Assay